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A slow and steady revolution is sweeping the market for erectile dysfunction drugs – Cialis. Most people may not even be aware of it. Lilly ICOS, the pharmaceutical alliance, which launched the blockbuster drug Cialis, announced that the drug has achieved 1 billion dollars in global sales since launching in Europe less than two years back.
In fact Cialis has become the top Erectile Dysfunction treatment in France, since January 2005, based on the latst market data, easily overtaking Viagra, the first brand to be launched in this market. It is also doing very well in United Kingdom, Italy, Germany, United States, Canada, Australia, Mexico and Brazil.
So much so that a Lilly ICOS press release contained these words from Rich Pilnik, President of Lilly's EMEA region "We are very pleased with the performance of Cialis and the steady development of the brand since its launch two years ago. Millions of men suffer from ED and the growth of the market demonstrates that patients are speaking to their healthcare providers about ED and seeking treatment options."
Not only has Cialis been able to expand the market but it has also eaten heavily in the market share of Viagra from Pfizer, the first drug to be launched in this market and Levitra from Glaxo-Bayer-Schering Plough. In fact Cialis was the second PDE5 inhibitor drug to become available in Europe. It is currently promoted in approximately 100 countries including the United States, Australia, Brazil, Mexico, Canada and across Europe and Asia for Erectile Dysfunction.
According to Paul Clark, Chairman and Chief Executive Officer of ICOS Corporation. "Passing the $1 billion mark is an important milestone for Lilly ICOS and a great accomplishment for the Cialis team. Since 2003, men with erectile dysfunction have had a choice of oral treatments for their condition - a condition which may impact on relationships and daily life."
Beyond all the hype and the jubilation is the sheer superiority of Cialis over all the other drugs available in this indication. To understand the benefits of Cialis, we need to firstly understand this complex condition.
Erectile Dysfunction or Impotence is defined as the inability to ensure and maintain an erection sufficient for sexual intercourse. ED affects an estimated 180 million men worldwide . 90 percent of ED cases are related to a physical or medical condition, such as diabetes, cardiovascular diseases, and prostate cancer treatment, while 10 percent are due to psychological causes . In many cases, however, both psychological and physical factors contribute to the condition.
Where physical factor play an important role PDE-5( Phosphodiaterase) inhibitors have a significant role to play. These include drugs like Sildenafil (Viagra) and Vardenafil(Levitra). But none are as good as Tadalafil(Cialis). Why?
Firstly let’s understand how PDE-5 inhibitors work. They work by inhibiting the enzyme phosphodiasterase-5 which is responsible for degrading another enzyme called cGMP(cyclic Guanosine Mono Phosphate) which through a series of reactions is responsible for the synthesis of nitric oxide. Nitric oxide is an important vasodilator responsible for dilation of the blood vessels that supply blood to the penis. Thus, there is an increase in the blood supplied to the penis and this increased blood engorges the penis and leads the formation of an erection through hydraulic pressure.
All PDE-5 inhibitors work in the same way but because they are different molecules, they also have different properties. The body quickly eliminates both Sildenafil and Vardenafil. Therefore their action lasts for only 4 hours, while Tadalafil(Cialis) is absorbed and eliminated slowly therefore it remains in the body for a longer period of time. Therefore its duration of action is 9 times that of other drugs - 36 hours. This ensures that Cialis will act over a whopping 36 hours and any patient on Cialis does not need to have hurried sex , but sex at his or his partner’s leisurely pace. That is why Cialis has been nicknamed as “Le Weekend Pill” in France. It allows the man to relax with his partner and have spontaneous sex.
Also other drugs like Viagra act on the enzyme PDE-6, which is found in the eyes, leading to bluish discolouration of vision, which will not occur with Cialis.
Cialis can be taken with a 100% fat meal and there will be no change in it’s action. The same is not true for Sildenafil or Vardenafil, which are affected by food.
All this makes Cialis currently the best drug for erectile dyfunction.
What further adds to it’s appeal are programmes like “The Cialis Promise” from Lilly ICOS which guarantees free trial with a rival drug in case Cialis does not work. With this kind of confidence oozing from Lilly ICOS, there is reason to believe in the promise of Cialis.
Cialis is available at any neighbour chemist on providing a doctor’s prescription or one can buy Cialis online. An online prescription is generated on filling a short form and on payment through credit card, one can be rest assured of getting Cialis discreetly. What more cheap generic Cialis is also available online. This will further reduce your medical bills. The low cost is like an icing to the Cialis cake or pudding for that matter . But, as is said, the proof of the pudding lies in the eating - So go for Cialis.
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Anyone can become enraged once in a while. But if you feel rage boiling within almost constantly, or rage erupts from you frequently, you may have an organic illness.
On the other hand, you might have suffered some terrible injustice as a child.
One major, but largely ignored, category of such abuse is that of boys emotionally, physically, or sexually damaged by women.
This abuse is not only widespread but may be at the root of much subsequent abuse of women by men.
A little boy abused by a woman suffers in similar ways to a little girl abused by a man.
In recent times it has become acceptable for women to speak out about the abuse they suffered as children; most men feel no such permission is given to them about the abuse they suffered as little boys at the hands of women. These men are ashamed, and enraged.
They are enraged because society accepts that men can be angry but there is less acceptance for the male victims' feelings of hurt, fear, inadequacy, guilt, embarrassment, and especially weakness and vulnerability.
A male victim smothers these emotions with anger. In this way, he preserves his masculine image. But the cost is enormous.
A man unaware of the deep sources of his anger will, at the least, have troubled relationships with women; at the worst, he may rape and mutilate.
A male victim of childhood sexual abuse by women displays the following behavior as an adult:
>> Distrust of women.
>> Fear of intimacy.
>> No separate identity.
>> Readily feels guilt.
>> Hard time to accept compliments.
>> Holds back emotions.
>> Protects abuser(s).
>> Sexual difficulties.
>> Seeks abuser's approval.
>> Constantly apologises.
>> Fearful.
>> Eager to care for others.
>> Joyless. (Adapted from Blanchard, 1987*)
The lousy feelings often erupt as rage. Ronald sought professional help to change his vicious behavior toward his wife, Helen.
Ronald would arrive home disgruntled after a disappointing day (every day was disappointing) in the architectural office where he worked, and an hour's drive to the suburb.
Before long, he would be kicking Helen. There was always some pretext for the kicks. (Helen did not have supper ready, or she was on the phone, or she wore a dress he hated...). Ronald never used his fists. Always his legs. He despaired of his uncontrollable rage because he believed that “Helen was the best thing that had ever happened to me.”
As Ronald talked more about his life, his hostility to almost everyone became evident. He was jealous of his brothers, sneered at their choices of wives, hated his job where he felt put upon, especially by female colleagues.
When Ronald spoke about his mother, he whined. Long stories of how she favored one or other of his brothers, how he cringed in her presence, how he avoided visits to her house yet was jealous of her contacts with his siblings. Ronald was convinced his mother preferred one of his nephews, adding bitterly, “Though my son was the first grandchild.”
Hypnotherapy Heals the Hurt and the Rage
Within the comfort of hypnosis Ronald was able to connect his present-day woes with unpleasant incidents in his childhood.
This was accomplished with what hypnotherapists call an “affect link.” You allow yourself to feel a particular emotion, such as grief. As you continue to experience the feeling, the hypnotherapist asks you to recall an earlier time when you felt the same way. Ronald's confused mix of bitterness, rage and sense of abandonment, swiftly drew up a memory of his mother:
“I'm six years old. Mummy keeps telling me I'm her favorite. She tells me to come into her bed. It's warm there. I fall asleep, snuggled beside her. I wake up. She's moving my leg up and down over this hairy place between her legs. She's breathing funny. I'm scared. [Sobs]. She opens her eyes a little and tells me it's okay. My knee is wet. I try to pull away but she holds onto me, tells me to be a good boy, do this for Mummy. She seems out of breath. I'm scared. Then she shakes and cries out. I'm even more scared and I feel bad, like something's really wrong. I ask Mummy if she's all right. She turns to me with a big smile, hugs me and says I'm her little man and everything is fine. [More sobs, reddening of face].
“But everything is not fine. I don't understand. Mummy tells me this will be our special secret. She seems happy. And she likes me best. So I keep quiet. And whenever she asks me I let her use my leg to rub her where she wants. [Later Ronald described other sexual activity his mother initiated]. I begin to like it, too. When I get old enough to have an erection, Mummy plays with my penis. I really like that. But at the same time it feels kind of weird. This stuff went on till I was eleven. I found out at school what sex was supposed to be, and how bad it was what Mummy and me had been doing. I felt sick.”
With psychotherapy while he relaxed in hypnosis, Ronald made some progress toward a healthier life, and control of his rage.
Unfortunately, his wife sabotaged the treatment. Ronald, like many sexually abused victims, had (unconsciously) sought out a woman who would continue the abuse he had suffered as a child.
Helen had made no secret of her broad sexual experience prior to meeting Ronald; indeed, she was proud of it. But her knowledge of the carnal world and his relative innocence (sex with only one woman: his mother) repeated the power pattern Ronald had suffered as a boy.
When Helen saw that Ronald was learning to control his rage, to lessen his hostile attitude and to relax, she counterattacked. Helen had married Ronald because (unconsciously) she wanted a man she could dominate and despise. His therapy threatened to upset the delicate dance of danger they had created.
Ronald was swiftly reduced to a sniveling, angry puppet when Helen sneered at his progress and repeatedly reminded him of what a Mummy's boy he had been.
A final blow bounced Ronald out of therapy: Helen telephoned the therapist, discussed Ronald's history, and insisted the therapist not mention her call to Ronald. The following week Helen casually mentioned to Ronald something the therapist had said to her. Ronald felt betrayed [he was] and never returned to therapy.
You may be doing very well with hypnotherapy when a friend or relative sabotages your progress. This is not usually as dramatic or underhanded as Helen's behavior. The disruption comes in the form of doubt. Your friend may question the effectiveness of hypnosis, and cite the many hypnosis myths that still pollute our minds.
Once doubt is planted, hypnosis ends. Doubt and fear keep us from relaxation. And relaxation is the route into hypnotherapy.
Dennis, like Ronald, suffered fits of rage. Unlike Ronald, Dennis took these fits out on himself. He would tremble, and shake, and sweat and fear he was about to pass out. Dennis knew his ambition to become a police officer would never be realized unless he got over these fits. Like Ronald, he had troubled relationships with women.
Unlike Ronald, Dennis had slept with dozens of women. All his longer-term relationships collapsed over an aspect of jealousy, his or hers. Didn't matter. Dennis could not trust a woman.
Dennis deliberately sought out a male psychotherapist who sometimes used hypnosis. But so scared was Dennis of going into hypnosis, that he spent several sessions in traditional psychotherapy before he had plucked up enough courage to try hypnosis.
Mothers Are Not The Only Women Who Abuse Little Boys
As far as Dennis knew, he had not been molested by his mother. Actually, he was not even sure who his biological mother was. He had been born into a large, extended criminal family. He had lived in seven different homes by the time he was five. All but one were homes of his aunts, cousins or siblings. He got used to calling each aunt in turn “mother.” The woman listed on his birth certificate showed no more, and no less, maternal interest in Dennis than did any of her sisters who raised him.
From as far back as he could remember, Dennis had been abused: abandoned, ignored, ill-fed, beaten, locked in a closet.
The therapist helped Dennis sort out the multitude of feelings that swirled within him.
Finally, Dennis said he was ready to try hypnosis. He was still frightened, despite the therapist's explanations about the safety of the process. But it was not hypnosis itself that Dennis feared; it was what might be uncovered.
In one way, he was right to be wary. But what was uncovered, awful as it was, freed Dennis from the last symbolic chains that linked him to his abusive family and their criminal ways.
In hypnosis, Dennis traced his attacks of trembling to some disgusting sexual behavior of one of his aunts when he was about four. What she had done to him and with him amounted to torture. It had been so horrible he had repressed the details for years, though “I knew something had happened; I just didn't know what.”
Now that he knew what lay at the root of his rage and his attacks, Dennis was able to let go of them. He felt forgiveness for his aunt because he knew of her own dreadful background. It was as if to know what she had done liberated Dennis from any lingering loyalty to his criminal relatives (all of whom were involved in drug deals, prostitution, extortion, etc.).
Now Dennis felt fully comfortable with his decision to apply to the local police training college.
*Blanchard, Geral. (1987). Male Victims of Child Sexual Abuse: A Portent of Things to Come, Journal of Independent Social Work, 1-1, 19-27.
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The resent passing of another HIV (Human immunodeficiency virus) testing awareness day this summer made me think about some of my old clients. I was a state certified HIV test counselor for the state of Michigan at the agency where I worked. This meant that I administered HIV tests for those people who believed that they may have been put at risk for contracting HIV, the virus that causes AIDS. This was a stressful job, and some days, down right awful. The awful days, as you can imagine, were the ones when I had to tell a client that they had tested positive for the HIV antibodies. Thankfully, I only had to tell a few people, but those few individuals are forever carved into my mind. I will never forget them or the day that I had to tell them that they most likely were infected with a life altering infection. These people were young, old, and middle aged. They were people not unlike me. Hard working, dedicated to family, goal oriented, future driven. They were beautiful people that are going through life with an ugly, incurable illness. Unfortunately for me, since these individuals tested anonymously, I will never know their true identities and will probably never know how they are and if they are living healthy productive lives, or suffering and alone.
Guess what? You could be infected. You could be at risk. You should be one of those clients that walks into an office and asks to be tested. HIV doesn’t discriminate. It doesn’t care if you are rich or poor. If you are male or female. Gay or straight. It doesn’t care how old you are. We have babies in this country still being born with the virus because moms don’t know they are infected. Parents and grandparents are increasingly being diagnosed with HIV. Yes, you need to know that your mom and dad or grandmom and grandpa still have sex. They still can potentially be infected if they are involved with someone sexually that has the virus. HIV is still out there. It is still killing people. We do not know yet how to stop it. Doctors and researchers are developing new ways all the time to slow it down, limit its effects on people’s lives, but we are no where near eliminating it from our world.
I have been working with educating about HIV for around 20 years. I am sad and horrified to look at the statistics and see that we are no better off now than we were 20 years ago. The numbers keep rising. There is much in the news about HIV/AIDS rates in Africa and other countries, but I want to remind people that in your own backyard, HIV is still raging. We need to remind people that there are safer ways to behave, to reduce the risk of the infection spreading. The best way to reduce the risk of spreading HIV is to know your own status. There are testing sites available in your state. Get a test. They only take a short time to administer, and usually you can do it without giving blood. You can, in many cases, do it anonymously. Testing is the only way that you will know if you are infected. The earlier the diagnosis, the better the prognosis. Don’t assume you only associate with non-risky people. You can’t possibly know. Ask anyone who has HIV.
As a society, we need to become more comfortable with talking about uncomfortable topics. We need to talk to potential partners. We need to talk to our doctors. We need to talk to our friends. I remember thinking when I was a teenager that I wanted to be just like Dr. Ruth Westheimer when I grew up. She was so great about telling it like it was. She called a penis a penis and was proud to do so. I admired that in a time when people didn’t talk to teens about sex, she was willing to. Today, we seem to only talk to teens. We stop talking once that teen grows up. They has become very apparent due to the increasing number of adults over the age of 50 who are becoming infected. So now I am talking. The lessons are fairly simple. Know your HIV status. Know the infectious disease status of your sex partner, or don’t have sex. Use a condom. Don’t share needles if you are using drugs. If it isn’t possible to refuse every time, do it some of the time. Every time you think about your health and act positively for it, you reduce your risk and add another day to the fight against this illness. Find support. There are many wonderful agencies in communities across this country that offer education, help, and the things you need to live a safer life. Everyone has their own story and their own reason not to live safely. These agencies have been trained to help each individual create their own specific plan of action.
There are some people who feel that the drugs are available, so it is worth the risk. Certainly we risk getting the flu or infections by going out into the general public with the understanding that there are medications available to make us better if we get sick. So why is HIV different? One reason is that the drugs are expensive. Many people don’t have the insurance coverage to help pay for them, and even if they do, some drugs are hard to come by in certain areas. Secondly, the side effects for many of these drugs are brutal. I know people living with the virus who have chosen to deal with the disease rather than be restricted by the drugs. Another reason is that when you get Strep throat, you take an antibiotic for 10 days and you are done with that medication and that infection. If you get infected with HIV, you take medication for the rest of your life, with the added stress that if you forget to take it to often, it may become ineffective for you, all the while knowing that you never are going to be free of HIV.
It is as simple and straightforward as all that. Dr. Ruth couldn’t say it plainer. HIV can’t just be thought about on testing days or awareness days. It needs to be thought about, talked about, and dealt with daily. It needs to have people like you and me to continue to fight the fight for comprehensive sexuality education. To continue to educate everyone about what HIV is about and who it affects. We need to talk equally to young and old alike about the risks that they take with their lives. And mostly we need to not forget those that have died and continue to be infected and affected by a disease that is so easy to prevent. I know that I will always think about my clients and will pray that they are living happy healthy lives.
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When someone is experiencing hypothyroidism the thyroid gland is impaired, producing too little thyroid hormone. Hypothyroidism is due primarily to a dysfunction of the thyroid gland itself. If the thyroid gland is removed, obviously, the body is unable to produce any thyroid hormone. If the thyroid is partially removed, it may be able to produce enough hormones for a while, but over time it can become overworked and burn out. But the thyroid can also become impaired for many other reasons.
The thyroid consists of 2 lobes connected together in front of the neck just below the voice box. The hormones produced by the thyroid gland control the body’s metabolic rate and a dysfunction to this gland can affect every organ in the body. When the thyroid is under active it creates a general depression of many of the cellular systems and oxidative processes in the body that are needed for energy production. This can cause the metabolic activities in the cells to decrease. Metabolic wastes can then filtrate into the organs, causing them to become sluggish.
Deficiencies of thyroxin (the hormone produced by the thyroid) leave the body feeling tired and run down. As the metabolism slows down, weight gain and constipation are often experienced. Other symptoms of hypothyroidism include fatigue, lack of energy, intolerance to cold temperatures, menstrual irregularities, depression, sluggish reflexes, hair loss, dry, coarse skin, brittle nails and puffiness around the eyes. Typically symptoms present themselves slowly and often evade detection.
The most common cause of hypothyroidism is inflammation that damages the thyroid tissue. This damage causes the body’s immune cells, which normally fight infection, to attack the thyroid and leave them incapable of producing enough hormones.
Hypothyroidism is often seen in post-partum women and is often mistaken for post-partum depression. Medications, such as Lithium also cause thyroid dysfunction. While rare, disorders to the pituitary or hypothalamus glands in the brain can also lead to this and other hormonal imbalances.
Recommendations For Wellness
Reduce soy consumption. Soy can depress thyroid function and has been shown to cause goiters (an enlargement of the thyroid gland) in healthy individuals.
Alkalinize the body! This may help to prevent thyroid dysfunction in the first place.
Get rid of the saturated fats from your diet. Saturated fats have been found to inhibit thyroid function.
Work to balance your estrogen levels. Estrogen slows down the thyroid gland.
Eat organically raised meats to avoid meats that are loaded with added hormones that have been introduced to increase the weight of livestock prior to sale.
Begin a hormonal balancing program using progesterone cream to help bring your body back into balance.
Vitamin B3, (niacin), which is often taken to reduce cholesterol levels, has been shown to also lower thyroid hormone levels.
Gentian is known to normalize the function of the thyroid gland.
Incorporate kelp and other sea vegetables that are high in iodine. Iodine is needed by the body to produce thyroid hormone.
Radishes have historically been used to treat thyroid problems and have been known to keep the levels of thyroid hormones balanced.
If depression due to hypothyroidism is a problem, try taking St. John’s Wort to help elevate your mood.
Chronic constipation can be addressed by adding additional dietary fiber such as psyllium to your diet. Herbal laxatives, such as cascara sagrada or Nature’s Sunshine’s LBS II can also be used as required.
Try supplementing with zinc and selenium. Studies indicate that severe zinc or selenium deficiencies can cause decreased thyroid hormone levels.
Coconut oil stimulates the thyroid gland and is a good choice for those suffering from an under active thyroid.
One of the most effective supplements for hypothyroidism is desiccated thyroid gland that comes from pigs. It was used long before synthetic forms of thyroid medications became available and is processed by the body more naturally.
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Sometimes in life, we all need a little boost whether it is a facelift, tummy tuck, rhinoplasty (nose job) botox or collagen injections or cosmetic dentistry, the end goal is the same. We want to improve our self image and feel better about the way we look. There is nothing wrong with this approach to life and that is why more and more men and women are turning to cosmetic surgery. Another cosmetic treatment that continues to grow in popularity is breast enlargement. This can be accomplished in two ways. You can either have breast augmentation using implants, or you can try natural breast enlargement pills. There are a number of excellent plastic surgeons performing breast enlargement procedures every day. Our only caution is to make sure they are highly qualified and experienced.
Many people wonder why women choose to have breast augmentation. Often after significant weight loss, childbirth or as we age, the breasts will lose their shape and size. Once this occurs, the breasts are no longer as attractive as they once were. According to women surveyed that had breast enlargement procedures, over 94% said they would recommend it to others. This is an overwhelming statistic in favor of breast augmentation. This procedure can be performed at any age once the breasts are fully developed. In the United States however, one must by 18 years of age or older for this form of plastic surgery. Now if you are not up for surgery, but still want larger breasts, you may opt for natural breast enlargement pills.
There are a number of natural breast enlargement pills on the market that advertise you will have firmer, rounder, natural looking breast in as little as 30 days. Some of the leading products on the market include Breast Gain Plus, Vanity, Femenique, Breast Success and Ultra Enhance Plus. You can likely find these products online if you want to do more research. Whether you increase your breast size naturally or through breast enlargement surgery, there are some benefits to consider. Data has shown that patients receive a psychological boost with breast augmentation, they are able to return to work often within a week, there is not evidence that it increases the risk of cancer or autoimmune diseases and there is no evidence it impacts one’s ability to get pregnant or breast feed.
